DNA METHYLATION-INDEPENDENT GROWTH RESTRICTION AND ALTERED DEVELOPMENTAL PROGRAMMING IN A MOUSE MODEL OF PRECONCEPTION MALE ALCOHOL EXPOSURE

DNA methylation-independent growth restriction and altered developmental programming in a mouse model of preconception male alcohol exposure

The preconception environment is a significant modifier of dysgenesis and the Hand Tool Set development of environmentally-induced disease.To date, fetal alcohol spectrum disorders (FASDs) have been exclusively associated with maternal exposures, yet emerging evidence suggests male-inherited alterations in the developmental program of sperm may be

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Effects of reflector, surface treatment, and length of scintillation crystal on the performance of TOF-DOI PET detector with dual-ended readout

The purpose of this study was to investigate the effect of the reflector, surface treatment, and length of scintillation crystals on the performance of a time-of-flight and depth-of-interaction (TOF-DOI) PET detector with Sofa a dual-ended readout and to determine the best reflector and surface treatment.Various types of crystal arrays with three d

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Molecular Docking, ADMET Study, Synthesis, Characterization and Preliminary Antiproliferative Activity of Potential Histone Deacetylase Inhibitors with Isoxazole as New Zinc Binding Group

Histone acetylation is a highly interesting epigenetic target for drug therapy.Histone deacetylase enzymes (HDACs) are overexpressed in several diseases, including cancers.Most of the clinically used HDAC inhibitors involve hydroxamate group Evening Gown as a zinc-binding group (ZBG).Hydroxamates have a poor pharmacokinetic properties and high toxi

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